Abstract: In order to solve the problems of poor roof stability, high stress concentration intensity, frequent failure of the traditional support and others during the withdrawal process of isolated island working faces, taking the isolated island working face of Meiyukou Mine as the research object, an optimization strategy for withdrawal support based on pressure relief belt roadway layout is proposed. By constructing a surrounding rock-support collaborative deformation control model, and conducting FLAC^3D numerical simulation analysis, the spatial relationship between the position, width, and stress peak of the pressure relief belt is clarified, and the structural parameters of the support are optimized. Aiming at the "three in one" collaborative support system, the response path and force allocation mechanism of anchor rods, anchor cables, and yielding component elements are designed, and the yielding itinerary is calculated based on the energy dissipation model. The on-site testing and monitoring results show that this scheme can effectively reduce the amplitude of roof subsidence and roadway side convergence, improve the surrounding rock stability and the smooth coordination ability of the support system, and provide theoretical basis and engineering guidance for the safe withdrawal of isolated island working faces under similar conditions.