Abstract: In view of the difficult problems of poor roof stability, frequent support failures and others caused by complex geological conditions and deep high stress environment in the 113 _upper 01 working face of Guotun Coal Mine, a collaborative response model of support - mine pressure monitoring - ventilation system is constructed, which integrates on-site multi-source monitoring data and quantitatively analyzes the composite action mechanism of multi-factor such as geostress distribution, coal seam structure, mining and excavation progress and others on surrounding rock stability. Based on the coupling mechanism, a dynamic regulation and control strategy is introduced to achieve real-time closed-loop linkage between support parameters and mine pressure feedback. The engineering application shows that after optimization, the roof stability qualification rate of the working face is improved from 60% to 90%, the failure rate of the support system is decreased from 3% to 0.5%, the mine safety accident rate is decreased from 2.5% to 1.25%, and the annual average coal production is improved by 12%. This collaborative response mechanism significantly enhances the working face stability and production continuity, and provides technical support and practical path for safe and efficient mining of deep mines under the threat of rock burst.