Abstract: Aiming at the existing problems of data jumping, signal loss, false alarms and others in the safety monitoring system of Wenjiazhuang Mine under the strong electromagnetic interference environment, the study carries out anti-interference technology optimization design from five aspects such as power supply system isolation, signal transmission link, interference source suppression, sensor type selection, and central station software algorithm. By replacing the regulated power supply and backup lithium battery buffer system, transforming the grounding and communication link structures, installing EMI filters at the variable frequency source end, updating NDIR type sensors and strengthening their electromagnetic compatibility performance, and embedding Kalman filtering and MAD removal algorithm at the central station, the system stability and monitoring data accuracy are effectively improved. After implementation, the data jump rate is decreased by over 90%, and the UWB positioning error can be controlled within 0.5 m, which enhances the reliability and practicality of the safety monitoring system in mines.