Abstract: Aiming at the problems such as low reservoir permeability,the compound plugging of mechanical and physicochemical are prone to occurr during the development process,and so on in the deep coalbed methane field （buried deep at 1850-2100 m） of Jinshan Coal Mine in Fuquan,Guizhou Province,based on the theories of sound pressure effect,cavitation effect,and acoustic flow effect of acoustic wave in reservoirs,a study of acoustic wave-chemistry synergistic plug removal technology is carried out.The optimal combination of acoustic wave parameters is screened through indoor comparative experiments,and the optimal process scheme for injecting 1.5% concentration quaternary ammonium salt plug removal agent after acoustic wave pretreatment is determined.The on-site application results show that this technology increases the average production of the three coalbed methane wells in the experimental area by 89.7%,and the production decline rate within 6 months is only 2.3%/month,which is 39.5% lower than the conventional plug removal process （3.8%/month）.The investment payback period is only 35 days,which has significant technical and economic benefits.